In recent years, there have been notable successes in commercializing organic photovoltaics (OPV) for new applications. In the laboratory, their power conversion efficiency has exceeded 20% on the cell level using the spin-coating technique. However, the still relatively low performance for large OPV modules, with limited thermal and light stability, has remained a bottleneck for wider adoption. We focused on using a Sheet-to-Sheet and Roll-to-Roll compatible slot-die coating method to fabricate organic photovoltaic cells and modules in ambient conditions, achieving performance similar to that of spin-coated devices. The compatibility of the coating technique was studied across different OPV architectures by fabricating devices using a commercially available Indium tin oxide transparent electrode. The long-term thermal stability of different OPV architectures was studied to identify the degradation pathways. Additionally, we showed long-term light-soaking stability for over 800 hours. Further, to unlock the full Roll-to-Roll compatibility, we adopted a hybrid approach that combines the advantages of R2R vacuum and solution coating methods for fabricating organic solar modules on glass and flexible polyethylene terephthalate (PET) in a top-illumination configuration. The opaque bottom electrodes were developed using R2R sputtering to achieve low sheet resistance and reduced surface roughness. The remaining layers in the devices, including the top transparent silver nanowire (AgNWs) anodes, were optimized using an R2R-compatible slot-die coating method at ambient conditions with greener solvents. We achieved the best PCE of 11.5 % for an ITO-free flexible mini-module. We believe our findings will pave the way for the development of greener, low-cost, and stable organic photovoltaics.